The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells.

@article{Gilbertson2008TheEO,
  title={The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells.},
  author={Lars Gilbertson and Sang-Ho Ahn and Pang-ning Teng and Rebecca K. Studer and Christopher Niyibizi and James D. Kang},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2008},
  volume={8 3},
  pages={449-56}
}
BACKGROUND CONTEXT Bone morphogenetic proteins (BMPs) are potential therapeutic factors for degenerative discs, and BMP-12 does not have the osteogenic potential of BMP-2, making it better suited for intradiscal injection. However, no reports have compared the actions of BMP-2 and -12 on human annulus fibrosus (AF) and nucleus pulposus (NP) cells nor evaluated adenoviral-mediated gene therapy in human AF cells. PURPOSE To evaluate and compare the effects of recombinant human (rh) BMP-2, rhBMP… CONTINUE READING

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