The effects of recombinant CSF-1 on the blast cells of acute myeloblastic leukemia in suspension culture.

@article{Miyauchi1988TheEO,
  title={The effects of recombinant CSF-1 on the blast cells of acute myeloblastic leukemia in suspension culture.},
  author={Jun Miyauchi and C Wang and C A Kelleher and Gordon G. Wong and Steven C. Clark and Mark D Minden and E A Mcculloch},
  journal={Journal of cellular physiology},
  year={1988},
  volume={135 1},
  pages={55-62}
}
Recombinant hemopoietic colony-stimulating factors (CSFs), including GM-CSF, G-CSF and IL-3, have been shown to be effective stimulators of both self-renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor, recombinant CSF-1 (or M-CSF), on the growth of leukemic blasts in culture. CSF-1 was found to be active on some, but not all, blast populations. In sensitive cells, CSF-1 often stimulated the… CONTINUE READING