The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis.

@article{Ohno2003TheEO,
  title={The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis.},
  author={Hideaki Ohno and Guofeng Zhu and Vellore P Mohan and Darien Chu and Shigeru Kohno and William Robert Jacobs and John Chan},
  journal={Cellular microbiology},
  year={2003},
  volume={5 9},
  pages={637-48}
}
Nitric oxide (NO) and related reactive nitrogen intermediates (RNI) are effective antimycobacterial agents and signal-transducing molecules. The present study uses microarray analysis to examine the effects of RNI on Mycobacterium tuberculosis gene expression. A common set of 53 genes was regulated by two chemically distinct nitric oxide donors. For a subset of the RNI-inducible genes, evidence exists suggesting that they may play a role in promoting survival of the tubercle bacillus in the… CONTINUE READING

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