The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph.


BACKGROUND AND OBJECTIVE Protamine is routinely administered following cardiopulmonary bypass in order to neutralize the effects of heparin. An excess of protamine can contribute to coagulopathy, hence predisposing to bleeding with associated morbidity and mortality. Thromboelastography (TEG) is recognized as an invaluable bedside tool to detect coagulation… (More)
DOI: 10.1097/EJA.0b013e32833731bd

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