The effects of prostaglandin E1 and prostaglandin E2 on in vitro myometrial contractility and uterine structure.

@article{Chiossi2012TheEO,
  title={The effects of prostaglandin E1 and prostaglandin E2 on in vitro myometrial contractility and uterine structure.},
  author={Giuseppe Chiossi and Maged M. Costantine and Egle Bytautiene and Talar B Kechichian and Gary D. V. Hankins and Elena Sbrana and George R. Saade and Monica Longo},
  journal={American journal of perinatology},
  year={2012},
  volume={29 8},
  pages={
          615-22
        }
}
OBJECTIVE To estimate the effects of prostaglandin E1 (PGE1) and E2 (PGE2) on myometrial contractility and structure in vitro. STUDY DESIGN Myometrial strips from 18 women were incubated with PGE1 (10-5 mol/L), PGE2 (10-5 mol/L), or solvent (CTR) for up to 360 minutes in organ chambers for isometric tension recording. The area under the contraction curve, total collagen content, and percentage of the area covered by connective tissue were calculated at various time periods. RESULTS PGE1… CONTINUE READING
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