The effects of prolonged isoflurane anaesthesia on cerebral blood flow and metabolism in the dog.

@article{Roald1989TheEO,
  title={The effects of prolonged isoflurane anaesthesia on cerebral blood flow and metabolism in the dog.},
  author={O K Roald and Minna Forsman and Petter Andreas Steen},
  journal={Acta anaesthesiologica Scandinavica},
  year={1989},
  volume={33 3},
  pages={210-3}
}
To determine whether cerebral blood flow (CBF) changed with time under isoflurane anaesthesia, as has been reported for halothane, CBF and cerebral metabolic rate for oxygen (CMRO2) were studied in five dogs under prolonged isoflurane anaesthesia. CBF was measured with a modified sagittal sinus technique and CMRO2 was calculated as the product of CBF and the arteriovenous O2 difference. Maintaining this experimental dog model with 1% isoflurane in oxygen and nitrogen for 3 h in five dogs and… CONTINUE READING