The effects of prior radiation therapy and age on the frequency and duration of complete remission among various four-drug treatments for advanced Hodgkin's disease.

@article{Cooper1984TheEO,
  title={The effects of prior radiation therapy and age on the frequency and duration of complete remission among various four-drug treatments for advanced Hodgkin's disease.},
  author={Michael R. Cooper and Thomas F. Pajak and A. J. Gottlieb and Arvin S. Glicksman and Nis I. Nissen and Frederick C. Richards and Clara D. Bloomfield and James F. Holland},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1984},
  volume={2 7},
  pages={748-55}
}
The current report examines the clinical response observed in 137 patients with advanced Hodgkin's disease who had relapsed from an initial complete response following radiation therapy (RTF) in comparison to 280 patients with no prior therapy (NPT). Patients were prospectively randomized to therapy with a four-drug combination chemotherapy program to determine whether CCNU and/or vinblastine are more effective than mechlorethamine and/or vincristine when combined with procarbazine and… CONTINUE READING