The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0).

@article{Martini1988TheEO,
  title={The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0).},
  author={Nael Martini and Mark G. Kris and Richard J. Gralla and Manjit S. Bains and Patricia M. E. McCormack and Larry Robert Kaiser and Michael E. Burt and Muhammad B. Zaman},
  journal={The Annals of thoracic surgery},
  year={1988},
  volume={45 4},
  pages={370-9}
}
We have defined "clinical N2" disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic… CONTINUE READING