The effects of prenylamine on single ventricular myocytes of guinea‐pig

@article{Shimoni1988TheEO,
  title={The effects of prenylamine on single ventricular myocytes of guinea‐pig},
  author={Y. Shimoni and P. Posner and A. J. Spindler and D. Noble},
  journal={British Journal of Pharmacology},
  year={1988},
  volume={94}
}
1 The action of prenylamine, an antianginal drug, was studied in single ventricular guinea‐pig myocytes. In concentrations of 10–50 μm, prenylamine significantly (P < 0.01) shortened action potentials, and significantly (P < 0.001) reduced the inward calcium current by 29% to 76% (n = 7). This effect was also present in the presence of adrenoceptor‐blockade (with phentolamine and propranolol), and was thus not due to indirect changes in endogenous catecholamine action. 2 Prenylamine did not… Expand
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