The effects of postmenopausal hormone replacement therapy and oral contraceptives on the endogenous estradiol metabolism.

@article{Mueck2001TheEO,
  title={The effects of postmenopausal hormone replacement therapy and oral contraceptives on the endogenous estradiol metabolism.},
  author={Alfred Otto Mueck and Harald Seeger and Thomas Graeser and Michel Oettel and Theodor Hermann Lippert},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2001},
  volume={33 12},
  pages={744-7}
}
The estradiol metabolism may be of clinical relevance in the pathophysiology of various diseases; the increase in D-ring metabolites over A-ring metabolites in breast cancer patients is of special interest. Since estrogen therapy has been blamed for increasing the risk of breast cancer, the effects of hormonal replacement therapy (HRT) and oral contraception were investigated on the ratio of the main D-ring metabolite, 16alpha-hydroxyestrone (16-OHE1), to the main A-ring metabolite, 2… CONTINUE READING