Corpus ID: 6188058

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

@article{Middleton2000TheEO,
  title={The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.},
  author={Elliott Middleton and Chithan C. Kandaswami and Theoharis C. Theoharides},
  journal={Pharmacological reviews},
  year={2000},
  volume={52 4},
  pages={
          673-751
        }
}
Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3… Expand
Flavonoids and Immunomodulation
TLDR
This chapter provides a brief summary of the current knowledge of the immunomodulatory action produced by flavonoids in experimental models and human intervention studies. Expand
Flavonoids: Antioxidant Compounds for Plant Defence... and for a Healthy Human Diet
TLDR
Since abiotic stresses cause an increase in cellular ROS levels, these latter functions appear to be based on flavonoids’ antioxidant activity, similarly to their assumed positive effects for human health if used as dietary components, nutraceuticals or even pharmacological drugs. Expand
Antimicrobial activity of flavonoids
TLDR
Several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents. Expand
Anti-inflammatory properties of dietary flavonoids.
TLDR
It has been demonstrated that flavonoids are able to inhibit both enzymes, as well as other mediators of the inflammatory process such as reactive C protein or adhesion molecules, which contribute to the anti-inflammatory capacity of flavonoid. Expand
Flavonoids in Cancer Prevention and Therapy: Chemistry, Pharmacology, Mechanisms of Action, and Perspectives for Cancer Drug Discovery
Among the numerous products available from plants, the flavonoid superfamily plays a central role by its large number of molecules (over 6000) and also by the role these products occupy in the normalExpand
Revisión Anti-inflammatory properties of dietary flavonoids
Flavonoids are a group of natural substances that are located in sources of vegetal origin. More than 4,000 varieties of flavonoids have been identified. All of them are phenyl-benzopyrones of lowExpand
Protective role of flavonoids in cardiovascular diseases
TLDR
Based on the results of clinical studies, it would be suffice to say that flavonoids could be promising cardioprotective agents. Expand
Distribution and biological activities of the flavonoid luteolin.
TLDR
The ability of luteolin to inhibit angiogenesis, to induce apoptosis, to prevent carcinogenesis in animal models, to reduce tumor growth in vivo and to sensitize tumor cells to the cytotoxic effects of some anticancer drugs suggests that this flavonoid has cancer chemopreventive and chemotherapeutic potential. Expand
Effect of flavonoids on human health: old subjects but new challenges.
TLDR
This review summarizes the current patents on the health effects of various flavonoid compounds, and suggests the possible expectation that a wide variety of diseases are successful treated with newly-developed specific flavonoids or their derivatives in the near future. Expand
Interactions of Some Common Flavonoid Antioxidants
Flavonoids are a group of secondary metabolites of plants including fruits and vegetables and exhibit a wide range of health benefits. Flavonoids in forms of aglycones, glycosides and methylatedExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 1,211 REFERENCES
Bioavailability and health effects of dietary flavonols in man.
  • P. Hollman, M. Katan
  • Chemistry, Medicine
  • Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
  • 1998
TLDR
The extent of absorption of flavonoids is an important unsolved problem in judging their many alleged health effects, and pharmacokinetic studies with dietary quercetin glycosides showed marked differences in absorption rate and bioavailability. Expand
Naturally occurring flavonoids: structure, chemistry, and high-performance liquid chromatography methods for separation and characterization.
  • D. Das
  • Chemistry, Medicine
  • Methods in enzymology
  • 1994
TLDR
Flavanones undergo a series of transformations affecting the heterocyclic C ring to give rise to flavonoids, a class of naturally occurring organic phytochemicals derived from 2-phenylchromone. Expand
Flavonoids as antioxidants.
  • P. Pietta
  • Chemistry, Medicine
  • Journal of natural products
  • 2000
TLDR
This review presents the current knowledge on structural aspects and in vitro antioxidant capacity of most common flavonoids as well as in vivo antioxidant activity and effects on endogenous antioxidants. Expand
6 Flavonoids: Some Physiological and Nutritional Considerations
TLDR
Flavonoids by inhibiting ascorbic acid breakdown and thereby reducing the mutagenic potential of ageing tissues could be of some significance in both the ageing process and the incidence of disease. Expand
Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis.
TLDR
The wider distribution and the more abundant presence of flavonoids in the plant kingdom, together with the present results, suggest that flavonoid may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumors. Expand
Effects of flavonoids on the metabolism of xenobiotics.
TLDR
Possible effects of flavonoids on the metabolism of lipophilic normal body constituents such as steroids and bile acids should be considered, and additional research is needed to determine the extent to which dietary flavonoid can influence the in vivo metabolism of xenobiotics. Expand
Structural aspects of antioxidant activity of flavonoids.
TLDR
It can be concluded that Ep/2 values and iron chelating activity can almost completely describe the LPO inhibiting behaviour of the flavonoids. Expand
Effects of flavonoids on the metabolism of xenobiotics.
Flavonoids represent a large class of naturally occurring plant constituents that are consumed in substantial amounts by experimental animals and by human beings. The ability of flavonoids toExpand
Phytoestrogens: epidemiology and a possible role in cancer protection.
TLDR
Recent results suggesting that the diphenolic isoflavonoids and lignans are natural cancer-protective compounds are reviewed, finding epidemiologic investigations strongly support this hypothesis. Expand
The production of reactive oxygen species by dietary flavonols.
TLDR
It is demonstrated that the extracellular production of active oxygen species by dietary flavonols is not likely to occur in vivo but the potential for intracellular redox cycling may have toxicologic significance. Expand
...
1
2
3
4
5
...