The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users

@article{Jones2016TheEO,
  title={The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users},
  author={J. Jones and M. Sullivan and J. Manubay and S. Mogali and S. Comer},
  journal={Physiology & Behavior},
  year={2016},
  volume={159},
  pages={33-39}
}
  • J. Jones, M. Sullivan, +2 authors S. Comer
  • Published 2016
  • Medicine
  • Physiology & Behavior
  • AIMS Activation of PPARγ by pioglitazone (PIO) has shown some efficacy in attenuating addictive-like responses in laboratory animals. The ability of PIO to alter the effects of opioids in humans has not been characterized in a controlled laboratory setting. The proposed investigation sought to examine the effects of PIO on the subjective, analgesic, physiological and cognitive effects of oxycodone (OXY). METHODS During this investigation, nondependent prescription opioid abusers (N=17… CONTINUE READING
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