The effects of phosphate and acidosis on regulated thin-filament velocity in an in vitro motility assay.


Muscle fatigue from intense contractile activity is thought to result, in large part, from the accumulation of inorganic phosphate (P(i)) and hydrogen ions (H(+)) acting to directly inhibit the function of the contractile proteins; however, the molecular basis of this process remain unclear. We used an in vitro motility assay and determined the effects of… (More)
DOI: 10.1152/japplphysiol.00775.2012


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