The effects of phenobarbital pretreatment on the metabolism and toxicity of paraoxon in the mouse.

Abstract

The effects of induction of various forms of cytochromes P450 by chemicals like phenobarbital on the hepatic oxidative desulfuration and acute toxicity of the phosphorothioate insecticide parathion have been well-characterized. However, the effects of these chemicals on the metabolism and acute toxicity of the active metabolite paraoxon are less understood… (More)

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