The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.

@article{Wickenden1996TheEO,
  title={The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.},
  author={A. Wickenden and H. Prior and E. Kelly and K. Russell and S. Poucher and P. Kumar},
  journal={European journal of pharmacology},
  year={1996},
  volume={302 1-3},
  pages={
          79-88
        }
}
  • A. Wickenden, H. Prior, +3 authors P. Kumar
  • Published 1996
  • Chemistry, Medicine
  • European journal of pharmacology
  • The purpose of the present study was to investigate the functional consequences of KATP modulation in the normal and the metabolically inhibited guinea-pig isolated diaphragm using the K+ channel openers cromakalim, pinacidil, RP49356 (N-methyl-2-(3-pyridil)-tetrahydrothiopyran-2-carbothiami de-1-oxide) and ZM260384 (2-(2,2-bis(difluoromethyl)-6-nitro-3,4-dihydro-2H-1,4-benzoxazine -4-yl)pyridine-N-oxide) and the K+ channel inhibitors glibenclamide, phentolamine and ciclazindol. All K+ channel… CONTINUE READING
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