The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
@article{Wickenden1996TheEO, title={The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.}, author={A. Wickenden and H. Prior and E. Kelly and K. Russell and S. Poucher and P. Kumar}, journal={European journal of pharmacology}, year={1996}, volume={302 1-3}, pages={ 79-88 } }
The purpose of the present study was to investigate the functional consequences of KATP modulation in the normal and the metabolically inhibited guinea-pig isolated diaphragm using the K+ channel openers cromakalim, pinacidil, RP49356 (N-methyl-2-(3-pyridil)-tetrahydrothiopyran-2-carbothiami de-1-oxide) and ZM260384 (2-(2,2-bis(difluoromethyl)-6-nitro-3,4-dihydro-2H-1,4-benzoxazine -4-yl)pyridine-N-oxide) and the K+ channel inhibitors glibenclamide, phentolamine and ciclazindol. All K+ channel… CONTINUE READING
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References
SHOWING 1-10 OF 24 REFERENCES
Effects of cromakalim on the membrane potassium permeability of frog skeletal muscle in vitro
- Chemistry, Medicine
- British journal of pharmacology
- 1992
- 9
Modulation of ATP-sensitive K+ channel activity and contractile behavior in mammalian ventricle by the potassium channel openers cromakalim and RP49356.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1990
- 47
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells.
- Chemistry, Medicine
- European journal of pharmacology
- 1993
- 47
The effect of glibenclamide on frog skeletal muscle: evidence for K+ATP channel activation during fatigue.
- Chemistry, Medicine
- The Journal of physiology
- 1994
- 74
Sulphonylurea drugs no longer inhibit ATP-sensitive K+ channels during metabolic stress in cardiac muscle.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1993
- 96
Phentolamine blocks ATP sensitive potassium channels in cardiac ventricular cells.
- Chemistry, Medicine
- Cardiovascular research
- 1994
- 20
Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227)
- Chemistry, Medicine
- British journal of pharmacology
- 1992
- 59
A link between adenosine, ATP‐sensitive K+ channels, potassium and muscle vasodilatation in the rat in systemic hypoxia.
- Chemistry, Medicine
- The Journal of physiology
- 1993
- 77
Effect of channel blockers on potassium efflux from metabolically exhausted frog skeletal muscle.
- Chemistry, Medicine
- The Journal of physiology
- 1987
- 101
Effects of P1060 and aprikalim on whole‐cell currents in rat portal vein; inhibition by glibenclamide and phentolamine
- Chemistry, Medicine
- British journal of pharmacology
- 1993
- 27