The effects of perphenazine on the concentration of nortriptyline and its hydroxymetabolites in older patients.

@article{Mulsant1997TheEO,
  title={The effects of perphenazine on the concentration of nortriptyline and its hydroxymetabolites in older patients.},
  author={Benoit H. Mulsant and J P Foglia and Robert A. Sweet and Jules M. Rosen and Kim Hung Lo and Bruce G. Pollock},
  journal={Journal of clinical psychopharmacology},
  year={1997},
  volume={17 4},
  pages={318-21}
}
Twenty-five older patients who presented with psychotic depression were treated with a combination of nortriptyline and perphenazine. Plasma levels of nortriptyline, E-, and Z-10-OH nortriptyline (E- and Z-10-OH-NT) were measured before and after addition of perphenazine. The mean (+/-SD) initial nortriptyline dose was 59 +/- 24 mg/day, whereas the mean… CONTINUE READING