The effects of pentobarbital and related compounds on frog motoneurons

@article{Nicoll1980TheEO,
  title={The effects of pentobarbital and related compounds on frog motoneurons},
  author={Roger A Nicoll and J. Martin Wojtowicz},
  journal={Brain Research},
  year={1980},
  volume={191},
  pages={225-237}
}
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182 Citations
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36
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182 Citations

Blocking action of pentobarbital on receptors for excitatory amino acids in the guinea pig hippocampus
TLDR
The results indicate that Pent blocks receptors for excitatory amino acids in the hippocampus, and of the three different populations of the receptors, Quis receptors are the most sensitive to Pent and KA receptor are the least sensitive.
Actions of pentobarbitone and derivatives with modified 5-butyl substituents on GABA and diazepam binding to rat brain synaptosomal membranes
TLDR
The differential kinetics of, and effects of temperature, chloride ions, a benzodiazepine receptor antagonist and picrotoxinin upon pentobarbitone and diazepam enhancement of GABA binding, suggest that these drugs exert their actions upon GABA binding at different loci.
Potentiation of GABAA-receptor-mediated responses by barbiturates in the guinea-pig ileum.
Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: A study with muscimol
TLDR
The results support the contention that pentobarbital (a) directly acts on the postsynaptic chloride ionophore and (b) augments GABA‐mediated post Synaptic effects.
A comparison of the actions of pentobarbitone and etomidate on [3H]GABA binding to crude synaptosomal rat brain membranes
  • M. Willow
  • Biology, Chemistry
    Brain Research
  • 1981
Effect of benzodiazepines and pentobarbital on the GABA‐induced depolarization in cultured astrocytes
TLDR
This data indicates that cultured astrocytes from neonatal rat cerebral cortex are depolarized by GABA, and the influence of pentobarbital and benzodiazepines on the GABA response is tested.
DISTINCTION BETWEEN THE EFFECTS OF BARBITURATES, BENZODIAZEPINES AND PHENYTOIN ON RESPONSES TO γ‐AMINOBUTYRIC ACID RECEPTOR ACTIVATION AND ANTAGONISM BY BICUCULLINE AND PICROTOXIN
  • M. Simmonds
  • Biology, Chemistry
    British journal of pharmacology
  • 1981
TLDR
The spectrum of drug activity in reducing the potency of picrotoxin correlates well with the reported anticonvulsant effects of these drugs against kindled amygdaloid seizures.
Pentobarbital depressant effects are independent of GABA receptors in auditory thalamic neurons.
TLDR
In summary, the pentobarbital acted at low concentrations to depress thalamocortical neurons and reduced Na(+)-dependent rectification on depolarization and lowered the slope resistance over a wide voltage range.
Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.
TLDR
It is concluded that the gating of the GABAA receptor channel by PHB and PB is functionally similar to that produced by the natural agonist GABA alone, but distinct from that obtained when barbiturates modulate the response to GABA.
Effects of anticonvulsants on excitability and GABA sensitivity of cat dorsal root ganglion cells
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References

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REVERSAL OF THE ACTION OF AMINO ACID ANTAGONISTS BY BARBITURATES AND OTHER HYPNOTIC DRUGS
TLDR
PB reversed the effects of the other GABA antagonists, tetramethylenedisulphotetramine and isopropyl bicyclophosphate and also the non‐selective antagonism produced by strychnine, and applied iontophoretically in amounts which neither decreased the spontaneous neuronal firing rate nor affected the response to GABA or glycine, reversed the GABA antagonism induced by iontophile application of Bic.
Effects of flurazepam on amino acid-evoked responses recorded from the lobster muscle and the frog spinal cord
Studies on convulsants in the isolated frog spinal cord. I. Antagonism of amino acid responses.
TLDR
There are at least three distinct populations of neutral amino acid receptors on primary afferent terminals: a GABA‐like receptor, a taurine/beta‐alanine receptor, and a glycine‐ like receptor, which suggest that thePrimary afferent receptors for glycine differ from those on the somata of spinal neurones.
Pentobarbital and synaptic high-affinity receptive sites for gamma-aminobutyric acid
The blockade of GABA mediated responses in the frog spinal cord by ammonium ions and furosemide.
  • R. Nicoll
  • Biology
    The Journal of physiology
  • 1978
TLDR
The results suggest that furosemide acts primarily by blocking the conductance increase elicited by GABA, and provide indirect evidence that chloride ions are involved in generating the GABA depolarizations of primary afferent terminals and dorsal root potentials.
CNS depressants: Effects on post-synaptic pharmacology
The action of thyrotropin-releasing hormone, substance P and related peptides on frog spinal motoneurons.
  • R. Nicoll
  • Biology
    The Journal of pharmacology and experimental therapeutics
  • 1978
TLDR
Results suggest that if SP and TRH were released from synapses impinging on frog motoneurons they would exert a background excitatory action.
Pentobarbital: action on frog motoneurons
Analysis of amino acid responses on frog motoneurones
Pentobarbital: differential postsynaptic actions on sympathetic ganglion cells.
TLDR
The present results indicate that pentobarbital has remarkably selective actions on the sympathetic ganglion and indicate that blockade of ganglionic transmission by anesthetic concentrations of pentobarBital can be entirely explained by a postsynaptic action.
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