182 Citations
Blocking action of pentobarbital on receptors for excitatory amino acids in the guinea pig hippocampus
- BiologyExperimental Brain Research
- 2004
The results indicate that Pent blocks receptors for excitatory amino acids in the hippocampus, and of the three different populations of the receptors, Quis receptors are the most sensitive to Pent and KA receptor are the least sensitive.
Actions of pentobarbitone and derivatives with modified 5-butyl substituents on GABA and diazepam binding to rat brain synaptosomal membranes
- Biology, ChemistryNeurochemical Research
- 2004
The differential kinetics of, and effects of temperature, chloride ions, a benzodiazepine receptor antagonist and picrotoxinin upon pentobarbitone and diazepam enhancement of GABA binding, suggest that these drugs exert their actions upon GABA binding at different loci.
Potentiation of GABAA-receptor-mediated responses by barbiturates in the guinea-pig ileum.
- BiologyEuropean journal of pharmacology
- 1984
Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: A study with muscimol
- Biology, ChemistryJournal of neuroscience research
- 1982
The results support the contention that pentobarbital (a) directly acts on the postsynaptic chloride ionophore and (b) augments GABA‐mediated post Synaptic effects.
A comparison of the actions of pentobarbitone and etomidate on [3H]GABA binding to crude synaptosomal rat brain membranes
- Biology, ChemistryBrain Research
- 1981
Effect of benzodiazepines and pentobarbital on the GABA‐induced depolarization in cultured astrocytes
- Biology, ChemistryGlia
- 1988
This data indicates that cultured astrocytes from neonatal rat cerebral cortex are depolarized by GABA, and the influence of pentobarbital and benzodiazepines on the GABA response is tested.
DISTINCTION BETWEEN THE EFFECTS OF BARBITURATES, BENZODIAZEPINES AND PHENYTOIN ON RESPONSES TO γ‐AMINOBUTYRIC ACID RECEPTOR ACTIVATION AND ANTAGONISM BY BICUCULLINE AND PICROTOXIN
- Biology, ChemistryBritish journal of pharmacology
- 1981
The spectrum of drug activity in reducing the potency of picrotoxin correlates well with the reported anticonvulsant effects of these drugs against kindled amygdaloid seizures.
Pentobarbital depressant effects are independent of GABA receptors in auditory thalamic neurons.
- BiologyJournal of neurophysiology
- 2002
In summary, the pentobarbital acted at low concentrations to depress thalamocortical neurons and reduced Na(+)-dependent rectification on depolarization and lowered the slope resistance over a wide voltage range.
Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.
- BiologyThe Journal of physiology
- 1996
It is concluded that the gating of the GABAA receptor channel by PHB and PB is functionally similar to that produced by the natural agonist GABA alone, but distinct from that obtained when barbiturates modulate the response to GABA.
Effects of anticonvulsants on excitability and GABA sensitivity of cat dorsal root ganglion cells
- Biology, PsychologyNeuropharmacology
- 1981
References
SHOWING 1-10 OF 26 REFERENCES
REVERSAL OF THE ACTION OF AMINO ACID ANTAGONISTS BY BARBITURATES AND OTHER HYPNOTIC DRUGS
- BiologyBritish journal of pharmacology
- 1978
PB reversed the effects of the other GABA antagonists, tetramethylenedisulphotetramine and isopropyl bicyclophosphate and also the non‐selective antagonism produced by strychnine, and applied iontophoretically in amounts which neither decreased the spontaneous neuronal firing rate nor affected the response to GABA or glycine, reversed the GABA antagonism induced by iontophile application of Bic.
Effects of flurazepam on amino acid-evoked responses recorded from the lobster muscle and the frog spinal cord
- BiologyNeuropharmacology
- 1978
Studies on convulsants in the isolated frog spinal cord. I. Antagonism of amino acid responses.
- BiologyThe Journal of physiology
- 1975
There are at least three distinct populations of neutral amino acid receptors on primary afferent terminals: a GABA‐like receptor, a taurine/beta‐alanine receptor, and a glycine‐ like receptor, which suggest that thePrimary afferent receptors for glycine differ from those on the somata of spinal neurones.
Pentobarbital and synaptic high-affinity receptive sites for gamma-aminobutyric acid
- Biology, ChemistryBrain Research Bulletin
- 1976
The blockade of GABA mediated responses in the frog spinal cord by ammonium ions and furosemide.
- BiologyThe Journal of physiology
- 1978
The results suggest that furosemide acts primarily by blocking the conductance increase elicited by GABA, and provide indirect evidence that chloride ions are involved in generating the GABA depolarizations of primary afferent terminals and dorsal root potentials.
The action of thyrotropin-releasing hormone, substance P and related peptides on frog spinal motoneurons.
- BiologyThe Journal of pharmacology and experimental therapeutics
- 1978
Results suggest that if SP and TRH were released from synapses impinging on frog motoneurons they would exert a background excitatory action.
Pentobarbital: differential postsynaptic actions on sympathetic ganglion cells.
- BiologyScience
- 1978
The present results indicate that pentobarbital has remarkably selective actions on the sympathetic ganglion and indicate that blockade of ganglionic transmission by anesthetic concentrations of pentobarBital can be entirely explained by a postsynaptic action.