The effects of paroxetine and nefazodone on sleep: a placebo controlled trial

@article{Sharpley1996TheEO,
  title={The effects of paroxetine and nefazodone on sleep: a placebo controlled trial},
  author={Ann L Sharpley and David J. Williamson and Mary E J Attenburrow and Geoffrey Robert Pearson and Patricia A. Sargent and Philip J. Cowen},
  journal={Psychopharmacology},
  year={1996},
  volume={126},
  pages={50-54}
}
We studied the effect of acute (1 day) and subacute (16 days) administration of the new antidepressant, nefazodone (400 mg daily), and the selective serotonin re-uptake inhibitor (SSRI), paroxetine (30 mg daily), on the sleep polysomnogram of 37 healthy volunteers using a random allocation, double-blind, placebo-controlled design. Compared to placebo, paroxetine lowered rapid eye movement (REM) sleep and increased REM latency. In addition, paroxetine increased awakenings and reduced Actual… CONTINUE READING