The effects of pH on DNA methylation state: In vitro and post-mortem brain studies.

@article{Ernst2008TheEO,
  title={The effects of pH on DNA methylation state: In vitro and post-mortem brain studies.},
  author={Carl Ernst and Patrick O McGowan and Vesselina Deleva and Michael J. Meaney and Moshe Szyf and Gustavo Turecki},
  journal={Journal of neuroscience methods},
  year={2008},
  volume={174 1},
  pages={123-5}
}
Assessment of methylation state of DNA extracted from brain is becoming one of the most investigated issues in the study of epigenetics and psychopathology. pH effects in brain are known to affect gene transcription, though pH effects on DNA methylation state are unknown. We demonstrate in vitro using an artificially methylated plasmid that DNA methylation state remains stable, even under extreme pH conditions. Next, using two different genomic regions from human DNA, we assess methylation… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 11 references

Risk factors for suicide completion in major depression : a case – control study of impulsive and aggressive behaviors in men

Y wivedi, HS Rizavi, +3 authors GN Pandey
Am J Psychiatry • 2005

Methylomics in psychiatry: Modulation of gene-environment interactions may be through DNA methylation.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2004

Role of human ribosomal RNA ( rRNA ) promoter methylation and of methylCpGbinding protein MBD 2 in the suppression of rRNA gene expression

S angaspeska, B Stride, R Metivier, M Polycarpou-Schwarz, D Ibberson
J Biol Chem • 2004

Altered gene expressionofbrainderivedneurotrophic factor and receptor tyrosinekinaseB in postmortem brain of suicide subjects

K hoshal, S Majumder, +3 authors SM Sharma
Arch Gen Psychiatry • 2003

Rett syndrome is caused bymutations in XlinkedMECP 2 , encodingmethylCpGbinding protein 2

SJ lark, J Harrison, CL Paul, M Frommer
Nat Genet • 1999

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