The effects of pH and agitation on platelet preservation.

  title={The effects of pH and agitation on platelet preservation.},
  author={Makoto Bannai and Toshio Mazda and S Sasakawa},
  volume={25 1},
Platelet concentrates made with an initial pH of 7.85 or 6.85 by addition of alkali or acid were stored at 22 degrees C on tumbler or horizontal agitators. The combination of a high pH and use of a tumbler rotator was associated with a 40 percent reduction in platelet count, fragmentation of platelets, release of lactate dehydrogenase, and a marked loss in response to adenosine diphosphate. Similar, but less striking changes occurred in acidified platelet concentrates stored on the tumbler… CONTINUE READING