The effects of organic solvents on the folding pathway and associated thermodynamics of proteins: a microscopic view

  title={The effects of organic solvents on the folding pathway and associated thermodynamics of proteins: a microscopic view},
  author={Yuqi Yu and Jinan Wang and Qiang Shao and Jiye Shi and Weiliang Zhu},
  journal={Scientific Reports},
Protein folding is subject to the effects of solvation environment. A variety of organic solvents are used as additives for in vitro refolding of denatured proteins. Examination of the solvent effects on protein folding could be of fundamental importance to understand the molecular interactions in determining protein structure. This article investigated the folding of α-helix and β-hairpin structures in water and the solutions of two representative refolding additives (methanol (MeOH) and 1… 
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