The effects of orchidectomy and testosterone replacement therapy on plasma and brain oxytocin in normal rats.


In male rats, two-week orchidectomy induced a significant increase in the pituitary content of oxytocin-immunoreactivity and a significant fall in its hypothalamic concentration, without detectable changes in plasma. Testosterone replacement therapy in castrated animals abolished the stimulant effect of orchidectomy on pituitary accumulation of oxytocin… (More)