The effects of omega-3 polyunsaturated fatty acids supplementation in pregnancy, lactation, and infancy: an umbrella review of meta-analyses of randomized trials.

@article{Firouzabadi2022TheEO,
  title={The effects of omega-3 polyunsaturated fatty acids supplementation in pregnancy, lactation, and infancy: an umbrella review of meta-analyses of randomized trials.},
  author={Fatemeh Dehghani Firouzabadi and Sakineh Shab-Bidar and Ahmad Jayedi},
  journal={Pharmacological research},
  year={2022},
  pages={
          106100
        }
}
2 Citations
Effect of antenatal omega-3 supplementation on maternal depressive symptoms from pregnancy to 6 months postpartum: a randomized double-blind placebo-controlled trial.
TLDR
Comparison between groups showed no differences in the EPDS score at any time during pregnancy or postpartum, in both intention-to-treat and per-protocol analysis, but an earlier reduction in theEPDS score was observed in the omega-3 group, which may indicate a benefit of antenatal Omega-3 supplementation.
Neurovascular abnormalities in retinopathy of prematurity and emerging therapies.
TLDR
This review discusses neurovascular communication among retinal blood vessels, neurons and glial cells during retinal development and ROP pathogenesis and summarizes the current and emerging therapies to address unmet clinical needs for the disease.

References

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TLDR
The available low-quality evidence indicated that omega-3 fatty acids supplementation during pregnancy may reduce the incidence of wheeze/asthma of children, but incidence of asthma was not reduced after omega- 3 fatty acids supplements during pregnancy.
Omega-3 Long Chain Polyunsaturated Fatty Acids to Prevent Preterm Birth: A Systematic Review and Meta-analysis
TLDR
Omega-3 supplementation during pregnancy does not reduce the incidence of preterm birth or improve neonatal outcome and there were no significant differences in the subgroup analyses.
Omega-3 long-chain polyunsaturated fatty acids and fish oil supplementation during pregnancy: which evidence?
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TLDR
Omega-3 was not associated with prevention of PTB, PE, IUGR, gestational diabetes, SGA, post-partum depression or better children development, and there was not enough evidence to support the routine use of omega-3 supplementation during pregnancy.
Effect of maternal n-3 long-chain polyunsaturated fatty acid supplementation during pregnancy and/or lactation on adiposity in childhood: a systematic review and meta-analysis of randomized controlled trials
TLDR
No evidence is found that n-3 LCPUFA supplementation during pregnancy and/or lactation favourably affects child adiposity, and further high-quality trials are needed.
Omega-3 Long-Chain Polyunsaturated Fatty Acids for Extremely Preterm Infants: A Systematic Review
TLDR
Large-scale interventional studies are required to determine the clinical benefits of omega-3 LCPUFA, specifically in extremely preterm infants, during the neonatal period.
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TLDR
Omega-3 PUFAs have an overall significant small beneficial effect on perinatal depression, with important subgroup differences, and omega-3PUFA supplementation may be a promising (add-on) treatment for postpartum depression.
The efficacy and safety of omega-3 fatty acids on depressive symptoms in perinatal women: a meta-analysis of randomized placebo-controlled trials
TLDR
Omega-3 FA significantly improved depressive symptoms in perinatal women regardless of pregnant or postpartum and well-tolerated and the omega-3 response was linked to higher EPA proportion in Omega-3 formula and mild- to-moderate depression.
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