The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

Abstract

The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo. Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methylated DNA immunoprecipitation (MeDIP), sample labelling, hybridization… (More)
DOI: 10.1186/1868-7083-6-1

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