The effects of oestrogen and progesterone on insulin sensitivity in female rats.

@article{Kumagai1993TheEO,
  title={The effects of oestrogen and progesterone on insulin sensitivity in female rats.},
  author={Susumu Kumagai and Agneta Holm{\"a}ng and Per Bj{\"o}rntorp},
  journal={Acta physiologica Scandinavica},
  year={1993},
  volume={149 1},
  pages={91-7}
}
The effects of 17-beta-oestradiol (E2) and progesterone (P) on insulin sensitivity were determined in oophorectomized (OVX) rats by the euglycaemic hyperinsulinaemic clamp technique combined with measurements of insulin-stimulated 2-deoxy-D-glucose (2-DOG) transport and glycogen synthesis in white and red parts of the gastrocnemius, the extensor digitorum longus and soleus muscles as well as in the liver (only glycogen synthesis). OVX was followed by insulin resistance in the clamp measurements… CONTINUE READING