The effects of novel cathepsin E inhibitors on the big endothelin pressor response in conscious rats.

@article{Bird1992TheEO,
  title={The effects of novel cathepsin E inhibitors on the big endothelin pressor response in conscious rats.},
  author={J. E. Bird and Thomas L Waldron and Dillie Little and Magdi Asaad and Charles R. Dorso and G C Didonato and Jon A. Norman},
  journal={Biochemical and biophysical research communications},
  year={1992},
  volume={182 1},
  pages={224-31}
}
The aspartic protease, cathepsin E, has been shown to specifically cleave big endothelin (big ET-1) at the Trp21-Val22 bond to produce endothelin (ET-1) and the corresponding C-terminal fragment. To determine whether cathepsin E is a physiologically relevant endothelin converting enzyme (ECE), three novel and potent inhibitors of cathepsin E were… CONTINUE READING