The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.

@article{Gallelli2013TheEO,
  title={The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.},
  author={Luca Gallelli and Olimpio Galasso and Daniela Falcone and Stephen R Southworth and Marco Greco and Valeria Ventura and Patrizia Romualdi and Alvaro Corigliano and Rosa Terracciano and Rocco Savino and Elio Gulletta and Giampietro Gasparini and Giovambattista De Sarro},
  journal={Osteoarthritis and cartilage},
  year={2013},
  volume={21 9},
  pages={1400-8}
}
OBJECTIVE We investigated the effects of celecoxib, diclofenac, and ibuprofen on the disease-specific quality of life, synovial fluid cytokines and signal transduction pathways in symptomatic knee osteoarthritis (OA). DESIGN Ninety patients scheduled for a total knee arthroplasty (TKA) were randomized to six groups that were treated with low and high dosages of celecoxib, diclofenac or ibuprofen. At the time of the first admission (T0) and at surgery (T1 = 14 days after beginning of the… CONTINUE READING