The effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions.

  title={The effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions.},
  author={Christopher M. Yates and Michael J. E. Sternberg},
  journal={Journal of molecular biology},
  volume={425 21},
Non-synonymous single nucleotide polymorphisms (nsSNPs) are single base changes leading to a change to the amino acid sequence of the encoded protein. Many of these variants are associated with disease, so nsSNPs have been well studied, with studies looking at the effects of nsSNPs on individual proteins, for example, on stability and enzyme active sites. In recent years, the impact of nsSNPs upon protein-protein interactions has also been investigated, giving a greater insight into the… CONTINUE READING
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