The effects of nicotine, denicotinized tobacco, and nicotine-containing tobacco on cigarette craving, withdrawal, and self-administration in male and female smokers

  title={The effects of nicotine, denicotinized tobacco, and nicotine-containing tobacco on cigarette craving, withdrawal, and self-administration in male and female smokers},
  author={Sean P. Barrett},
  journal={Behavioural Pharmacology},
  • S. Barrett
  • Published 1 March 2010
  • Psychology
  • Behavioural Pharmacology
The effects of the acute administration of nicotine [through nicotine inhalers (NI) and placebo inhalers (PI)], nicotine-containing tobacco (NT), and denicotinized tobacco (DT), on smokers' subjective responses and motivation to smoke were examined in 22 smokers (12 male, 10 female; 11 low dependent, 11 high dependent). During four randomized blinded sessions, participants self-administered NI, PI, NT, or DT, and assessed their effects using Visual Analogue Scales and the Brief Questionnaire of… 

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Nicotine-Containing Versus De-Nicotinized Cigarettes: Effects on Craving and Withdrawal

Dissociating nicotine and nonnicotine components of cigarette smoking

Prolonged exposure to denicotinized cigarettes with or without transdermal nicotine.

Transdermal nicotine-induced tobacco abstinence symptom suppression: nicotine dose and smokers' gender.

Results from this laboratory study support the continued use of TN as a pharmacotherapy, and higher doses may ameliorate some abstinence symptoms, although the side effect profile, at least in the short term, may limit effectiveness, especially for women.

Sex differences in the influence of nicotine dose instructions on the reinforcing and self-reported rewarding effects of smoking

In women but not in men, the influence of nicotine on smoking reward and reinforcement is enhanced by accurate verbal information about the cigarette's nicotine dose, consistent with the notion that the smoking behavior of women, relative to men, may be more responsive to nonpharmacological factors.

Pharmacodynamic effects of new de-nicotinized cigarettes.

The de-nicotinized cigarettes may prove useful in evaluating effects of smoking independent of the delivery of nicotine, and extend previous research that suggested the process of smoking and components of tobacco smoke other than nicotine mediate some effects of cigarette smoking.

Dissociating the nicotine and airway sensory effects of smoking

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