The effects of naloxone on retinal ischemia in rats.

  title={The effects of naloxone on retinal ischemia in rats.},
  author={Tim T. Lam and K Takahashi and Mark O. M. Tso},
  journal={Journal of ocular pharmacology},
  volume={10 2},
The efficacy of naloxone (NL), a broad spectrum opioid antagonist, on retinal ischemia, was evaluated in a rat model of retinal ischemia with histopathologic and morphometric criteria. Two intraperitoneal injections of naloxone 3 mg/kg given immediately and 6 hr after reperfusion showed beneficial effects to the retina as evaluated at 2, 7, and 14 days after reperfusion. Morphologically, the naloxone-treated group showed better-preserved ganglion cells, nerve fiber layer, and inner nuclear… CONTINUE READING