The effects of muscle contraction and insulin on glucose-transporter translocation in rat skeletal muscle.

@article{Brozinick1994TheEO,
  title={The effects of muscle contraction and insulin on glucose-transporter translocation in rat skeletal muscle.},
  author={J. Brozinick and G. Etgen and B. Yaspelkis and J. Ivy},
  journal={The Biochemical journal},
  year={1994},
  volume={297 ( Pt 3)},
  pages={
          539-45
        }
}
The effect of electrically induced muscle contraction, insulin (10 m-units/ml) and electrically-induced muscle contraction in the presence of insulin on insulin-regulatable glucose-transporter (GLUT-4) protein distribution was studied in female Sprague-Dawley rats during hindlimb perfusion. Plasma-membrane cytochalasin B binding increased approximately 2-fold, whereas GLUT-4 protein concentration increased approximately 1.5-fold above control with contractions, insulin, or insulin + contraction… Expand
Effect of insulin and contraction up on glucose transport in skeletal muscle.
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The mechanisms involved in the decrease of the amount of GLUT4 translocated to the plasma membrane by altering the exercise-induced enhancement of glucose transport capacity should provide important knowledge to the understanding and managing peripheral insulin resistance. Expand
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The ability of exercise to utilize insulin-independent mechanisms to increase glucose uptake in skeletal muscle has important clinical implications, especially for patients with diseases that are associated with peripheral insulin resistance, such as non-insulin-dependent diabetes mellitus. Expand
Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents.
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It is reported that contraction and insulin additively stimulate glucose uptake in rat epitrochlearis muscles with normal (NG) and high (HG) glycogen contents, but the additive effect was only partial. Expand
Glucose transporter content and glucose uptake in skeletal muscle constructs engineered in vitro
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There was a significant increase in the basal 2-deoxyglucose uptake of myooids compared with adult control, contraction-stimulated, and insulin- Stimulated soleus muscles, suggesting that the glucose transport of the engineered myooid is similar in several respects to that observed in both fetal and denervated skeletal muscle tissue. Expand
Regulation of GLUT4 protein and glycogen synthase during muscle glycogen synthesis after exercise.
  • J. Ivy, C. Kuo
  • Biology, Medicine
  • Acta physiologica Scandinavica
  • 1998
TLDR
The second phase of glycogen synthesis appears to be related to an increased muscle insulin sensitivity, which apparently helps maintain an increased number of GLUT4 transporters associated with the plasma membrane once the contraction-stimulated effect on translocation has reversed. Expand
Electrical stimulation induces fiber type-specific translocation of GLUT-4 to T tubules in skeletal muscle.
TLDR
It is concluded that electrically induced contraction stimulates GLUT-4 translocation more in T tubules of WG than RG, and the physiological implications of this finding for glucose uptake by contracting RG and WG muscles is discussed. Expand
Electrical stimulation induces fiber type-specific translocation of GLUT-4 to T tubules in skeletal muscle.
TLDR
It is concluded that electrically induced contraction stimulates GLUT-4 translocation more in T tubules of WG than RG, and the physiological implications of this finding for glucose uptake by contracting RG and WG muscles is discussed. Expand
Insulin-induced Recruitment of Glucose Transporter 4 (GLUT4) and GLUT1 in Isolated Rat Cardiac Myocytes
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GLUT4 is the major glucose transporter to be recruited to the surface of cardiomyocytes in response to insulin; 2) these cells express a high level of GLUT1; and 3) intracellular GLUT4-containing vesicles consist of at least two populations, which is compatible with recently proposed models of GLut4 trafficking in adipocytes. Expand
Regulation of GLUT4 traffic and function by insulin and contraction in skeletal muscle.
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Current knowledge of these alternative pathways of GLUT4 regulation in skeletal muscle is summarized and it is suggested that p38 MAP kinase activation represents a point of convergence of the signaling pathways utilized by insulin and contraction to increaseGLUT4 activation at the cell surface. Expand
Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice
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These studies suggest that the high-fat–fed mouse is characterized by defects at multiple steps of the MGU system that are precipitated by different physiological conditions, and suggests that MGU is impaired during exercise by high- fat feeding due to a limitation in glucose phosphorylation. Expand
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