The effects of moxaverine on ocular blood flow in patients with age‐related macular degeneration or primary open angle glaucoma and in healthy control subjects

@article{Pemp2012TheEO,
  title={The effects of moxaverine on ocular blood flow in patients with age‐related macular degeneration or primary open angle glaucoma and in healthy control subjects},
  author={Berthold Pemp and Gerhard Garhofer and Michael Lasta and Doreen Schmidl and Michael Wolzt and Leopold Schmetterer},
  journal={Acta Ophthalmologica},
  year={2012},
  volume={90}
}
Purpose:  The phosphodiesterase inhibitor moxaverine has been shown to increase choroidal blood flow (BF) in young healthy subjects. The present study was performed to investigate the effect of intravenously administered moxaverine on ocular BF in patients with age‐related macular degeneration (AMD), primary open angle glaucoma (POAG) and in age‐matched control subjects. 

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References

SHOWING 1-10 OF 54 REFERENCES

Ocular blood flow in diabetes and age-related macular degeneration.

The 2 leading causes of blindness in adults in the industrialized nations, diabetic retinopathy and age-related macular degeneration, have been investigated thoroughly with respect to their pathogenesis and knowledge of the pathophysiological vascular states underlying these diseases is essential for the assessment and development of future therapies.

Ocular perfusion and age-related macular degeneration.

Although these studies lend some support to the vascular pathogenesis of AMD, it is not possible to determine if the choroidal perfusion abnormalities play a causative role in nonexudative AMD, if they are simply an association with another primary alteration, such as a primary RPE defect or a genetic defect at the photoreceptor level, orif they are more strongly associated with one particular form of this heterogeneous disease.

Effect of Viagra on the foveolar choroidal circulation of AMD patients.

Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects.

The data from the present study indicate that dual inhibition of endothelin receptors increases ocular blood flow in patients with glaucoma and healthy subjects.

The impact of ocular blood flow in glaucoma

Effect of systemic moxaverine on ocular blood flow in humans

This study aimed to investigate whether systemically administered moxaverine improves ocular blood flow and found it safe and effective to treat eye diseases associated with ocular perfusion abnormalities.

Simultaneous management of blood flow and IOP in glaucoma.

Treatments for glaucoma should be designed to both reduce IOP and improve ocular nutrient delivery, as the dependence of blood flow on perfusion pressure links ischemia to IOP.

The influence of magnesium on visual field and peripheral vasospasm in glaucoma.

  • A. GasparP. GasserJ. Flammer
  • Medicine
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
  • 1995
Magnesium improves the peripheral circulation and seems to have a beneficial effect on the visual field in glaucoma patients with vasospasm.

Effect of nimodipine on ocular blood flow and colour contrast sensitivity in patients with normal tension glaucoma

Nimodipine increases ONH and choroidal blood flow in NTG patients and improves CCS, the latter effect does not, however, seem to be a direct consequence of the blood flow improvement.
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