The effects of moxaverine on ocular blood flow in patients with age‐related macular degeneration or primary open angle glaucoma and in healthy control subjects

@article{Pemp2012TheEO,
  title={The effects of moxaverine on ocular blood flow in patients with age‐related macular degeneration or primary open angle glaucoma and in healthy control subjects},
  author={Berthold Pemp and Gerhard Garhofer and Michael Lasta and Doreen Schmidl and Michael Wolzt and Leopold Schmetterer},
  journal={Acta Ophthalmologica},
  year={2012},
  volume={90}
}
Purpose:  The phosphodiesterase inhibitor moxaverine has been shown to increase choroidal blood flow (BF) in young healthy subjects. The present study was performed to investigate the effect of intravenously administered moxaverine on ocular BF in patients with age‐related macular degeneration (AMD), primary open angle glaucoma (POAG) and in age‐matched control subjects. 
Vascular Response to Sildenafil Citrate in Aging and Age-Related Macular Degeneration
TLDR
It is suggested that vascular response of the choroid to sildenafil decreases with age, but is not affected by the presence of non-exudative or exudative AMD, providing insight into changes in vessel compliance in aging and AMD. Expand
Progress in the Treatment of Dry Age-Related Macular Degeneration
Atrophic age-related macular degeneration does not show obvious loss of visual function in the early stage, so it is not easy to be taken seriously. In the advanced stage, most of the patientsExpand
Evaluating ocular blood flow
TLDR
This article reviews several invasive and noninvasive techniques available for evaluating ocular BF, with a particular focus on Doppler Fourier domain optical coherence tomography (OCT) and OCT-angiography. Expand
Color Doppler Imaging Analysis of Retrobulbar Blood Flow Velocities in Primary Open-Angle Glaucomatous Eyes: A Meta-Analysis
TLDR
This meta-analysis suggests that CDI is a potential diagnostic tool for POAG. Expand
Novel possibilities in treatment of dry age-related macular degeneration
Age-related macular degeneration (AMD) is one of the most important cause of central vision lost in elderly. AMD is “wet” or “dry”, depending on choroidal neovascularization (CNV) presence.Expand
Recent advances in the management of dry age-related macular degeneration: A review
TLDR
Several pathways, including oxidative stress, deposits of lipofuscin, chronic inflammation and choroidal blood flow insufficiency, seem to play an important role in the pathogenesis of d-AMD and represent possible targets for new therapies. Expand
Complement pathway biomarkers and age-related macular degeneration
TLDR
St Stratifying patients by their AMD genetic profile may facilitate future AMD therapeutic trials resulting in meaningful clinical trial end points with smaller sample sizes and study duration. Expand
Recent developments in the management of dry age-related macular degeneration
TLDR
The Age-Related Eye Disease Study demonstrated a statistically significant protective effect of dietary supplementation of antioxidants (vitamin C, vitamin E, beta-carotene, zinc, and copper) on dry AMD progression rate and it was stated that the consumption of omega-3 polyunsaturated fatty acids, such as docosahexaenoic acid, has protective effects. Expand
State-of-the art pharmacotherapy for non-neovascular age-related macular degeneration
TLDR
The authors believe that, in addition to successful advancement of promising drugs, further research should be directed at tailoring therapy to specific patient groups, eventually employing a combinational therapy strategy. Expand
Update on current and future novel therapies for dry age-related macular degeneration
TLDR
Stem cells, ciliary neurotrophic factor, rheopheresis, ozonated autohemotherapy and prostaglandins show promise in stabilizing or improving visual acuity, and herbal supplementation with saffron, zinc monocysteine and phototrop may be helpful. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 54 REFERENCES
Ocular blood flow in diabetes and age-related macular degeneration.
TLDR
The 2 leading causes of blindness in adults in the industrialized nations, diabetic retinopathy and age-related macular degeneration, have been investigated thoroughly with respect to their pathogenesis and knowledge of the pathophysiological vascular states underlying these diseases is essential for the assessment and development of future therapies. Expand
Ocular perfusion and age-related macular degeneration.
TLDR
Although these studies lend some support to the vascular pathogenesis of AMD, it is not possible to determine if the choroidal perfusion abnormalities play a causative role in nonexudative AMD, if they are simply an association with another primary alteration, such as a primary RPE defect or a genetic defect at the photoreceptor level, orif they are more strongly associated with one particular form of this heterogeneous disease. Expand
Effect of Viagra on the foveolar choroidal circulation of AMD patients.
TLDR
Administration of sildenafil citrate didn't cause any statistically significant changes in the foveolar choroidal circulation of AMD patients. Expand
Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects.
TLDR
The data from the present study indicate that dual inhibition of endothelin receptors increases ocular blood flow in patients with glaucoma and healthy subjects. Expand
The impact of ocular blood flow in glaucoma
TLDR
The potential role of OBf in glaucoma is discussed and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP is discussed. Expand
Effect of systemic moxaverine on ocular blood flow in humans
TLDR
This study aimed to investigate whether systemically administered moxaverine improves ocular blood flow and found it safe and effective to treat eye diseases associated with ocular perfusion abnormalities. Expand
Simultaneous management of blood flow and IOP in glaucoma.
TLDR
Treatments for glaucoma should be designed to both reduce IOP and improve ocular nutrient delivery, as the dependence of blood flow on perfusion pressure links ischemia to IOP. Expand
A placebo-controlled 3-year study of a calcium blocker on visual field and ocular circulation in glaucoma with low-normal pressure.
TLDR
Nilvadipine (2 mg twice daily) slightly slowed the visual field progression and maintained the optic disc rim, and the posterior choroidal circulation increased over 3 years in patients with OAG with low-normal intraocular pressure. Expand
The influence of magnesium on visual field and peripheral vasospasm in glaucoma.
  • A. Gaspar, P. Gasser, J. Flammer
  • Medicine
  • Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
  • 1995
TLDR
Magnesium improves the peripheral circulation and seems to have a beneficial effect on the visual field in glaucoma patients with vasospasm. Expand
Effect of nimodipine on ocular blood flow and colour contrast sensitivity in patients with normal tension glaucoma
TLDR
Nimodipine increases ONH and choroidal blood flow in NTG patients and improves CCS, the latter effect does not, however, seem to be a direct consequence of the blood flow improvement. Expand
...
1
2
3
4
5
...