• Medicine
  • Published in
    The Journal of pharmacology…
    1999

The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses.

@article{Mellon1999TheEO,
  title={The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses.},
  author={R. Daniel Mellon and Barbara M. Bayer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={288 2},
  pages={
          635-42
        }
}
Acute administration of morphine alters various neuroendocrine and immune parameters via opioid receptors located within the central nervous system. Similar effects have been reported after systemic nicotine treatment. To examine the possible relationship between opioid and nicotinic receptor activation on the immune system, we compared the effects of morphine with both nicotine and the highly selective nicotinic agonist, epibatidine. Male Sprague-Dawley rats were treated with either morphine… CONTINUE READING

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