The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2.

@article{Yang2006TheEO,
  title={The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2.},
  author={Mei Yang and Paul A Cobine and Sabine Molik and Amornrat Naranuntarat and Roland Lill and Dennis R Winge and Valeria C Culotta},
  journal={The EMBO journal},
  year={2006},
  volume={25 8},
  pages={1775-83}
}
Many metalloproteins have the capacity to bind diverse metals, but in living cells connect only with their cognate metal cofactor. In eukaryotes, this metal specificity can be achieved through metal-specific metallochaperone proteins. Herein, we describe a mechanism whereby Saccharomyces cerevisiae manganese superoxide dismutase (SOD2) preferentially binds manganese over iron based on the differential bioavailability of these ions within mitochondria. The bulk of mitochondrial iron is normally… CONTINUE READING
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Regulation of S. cerevisiae FET4 gene expression by iron and oxygen

  • LT Jensen, VC Culotta
  • J Mol Biol
  • 2002
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