The effects of methyl beta-carboline-3-carboxylate on social interaction and locomotor activity when microinjected into the nucleus raphé dorsalis of the rat.

@article{Hindley1985TheEO,
  title={The effects of methyl beta-carboline-3-carboxylate on social interaction and locomotor activity when microinjected into the nucleus raph{\'e} dorsalis of the rat.},
  author={Shaun Hindley and Alex O. Hobbs and I. Alick Paterson and Malcolm H. T. Roberts},
  journal={British journal of pharmacology},
  year={1985},
  volume={86 3},
  pages={
          753-61
        }
}
Intraperitoneal and intracerebral injections of methyl beta-carboline-3-carboxylate (beta CCM) and intracerebral injections of RO 15-1788 were given to rats. The performance of the rats in the social interaction test was measured to determine if changes in social interaction induced by beta CCM were mediated in part by the nucleus raphé dorsalis (NRD). Intraperitoneal injections of beta CCM, 2 and 4 mg kg-1, reduced social interaction. Intracerebral microinjections of beta CCM (10-0.1 ng in 0.5… CONTINUE READING