The effects of methotrexate on the production and activity of interleukin-1.

@article{Segal1989TheEO,
  title={The effects of methotrexate on the production and activity of interleukin-1.},
  author={Refael Segal and Edna Mozes and Michael Yaron and B. Tartakovsky},
  journal={Arthritis and rheumatism},
  year={1989},
  volume={32 4},
  pages={370-7}
}
To explore the possibility that the mechanism of action of methotrexate (MTX) in rheumatoid arthritis (RA) is related to modulation of interleukin-1 (IL-1), the effects of MTX on IL-1 production and activity were evaluated. Human peripheral blood mononuclear cells and murine peritoneal and splenic cells were stimulated by lipopolysaccharide to produce IL-1. No inhibition of IL-1 synthesis or secretion caused by MTX treatment could be demonstrated either in vitro or in vivo, in patients with RA… CONTINUE READING

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