The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders

@article{Millard2017TheEO,
  title={The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders},
  author={Samuel J Millard and K. Weston-Green and K. Newell},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2017},
  volume={80},
  pages={743-765}
}
Approximately 10% of pregnant women are prescribed antidepressant drugs (ADDs), with selective serotonin reuptake inhibitors (SSRIs) the most widely prescribed. SSRIs bind to the serotonin transporter (SERT), blocking the reabsorption of serotonin by the presynaptic neuron and increasing serotonin levels in the synaptic cleft. The serotonergic system regulates a range of brain development processes including neuronal proliferation, migration, differentiation and synaptogenesis. Given the… Expand
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