The effects of low doses of pregabalin on morphine analgesia in advanced cancer patients.

@article{Mercadante2013TheEO,
  title={The effects of low doses of pregabalin on morphine analgesia in advanced cancer patients.},
  author={Sebastiano L Mercadante and G. Porzio and Federica Aielli and P. Mart{\'i}nez Ferrera and Luigi Codipietro and Claudio Lo Presti and Alessandra Casuccio},
  journal={The Clinical journal of pain},
  year={2013},
  volume={29 1},
  pages={15-9}
}
OBJECTIVES The aim of this study was to evaluate the opioid response in patients receiving morphine and pregabalin, independently from the presumed pain mechanisms, in comparison with patients receiving morphine treatment only. METHODS A multicenter prospective randomized controlled study was carried out in a sample of 70 advanced cancer patients with pain requiring strong opioids. Thirty-five patients (group MO) were randomized to receive sustained-release morphine using initial doses of 60… CONTINUE READING