The effects of locally injected antibiotic on carrageenan-induced granuloma in rats.

@article{Maroussem1984TheEO,
  title={The effects of locally injected antibiotic on carrageenan-induced granuloma in rats.},
  author={D. de Maroussem and B. Pipy and M. B{\'e}raud and R. Derache},
  journal={European journal of pharmacology},
  year={1984},
  volume={99 4},
  pages={
          303-11
        }
}
  • D. de Maroussem, B. Pipy, +1 author R. Derache
  • Published 1984
  • Chemistry, Medicine
  • European journal of pharmacology
  • Indomethacin (0.5 mg/100 g b.w./day) and chloramphenicol (0.5 mg or 15 mg/100 g b.w./day) were tested for their anti-inflammatory effects on 7th day carrageenan-induced granuloma formation. Neither of the drugs modified granuloma or pouch wall weight but they decreased the exudate and the cluster of dead cells. Indomethacin and chloramphenicol decreased glucosamine in the dead cell granuloma fraction and increased the level of collagen in the pouch wall. The drugs differed in their inhibitory… CONTINUE READING

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