The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species.

@article{Baranowski1986TheEO,
  title={The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species.},
  author={Richard Baranowski and Bruce Lynn and Adrian Pini},
  journal={British journal of pharmacology},
  year={1986},
  volume={89 2},
  pages={267-76}
}
By examination of compound action potentials in the saphenous nerve of the anaesthetized rat it has been shown that capsaicin causes a rapid, dose-dependent, failure of conduction in many C-fibres when applied directly to the nerve. A large reduction in C-fibre conduction occurs with concentrations as low as 110 microM. After a 15-30 min exposure to capsaicin, only partial recovery occurs in 1 h. Similar block of C-fibre conduction occurs in the ferret. However, only smaller, reversible… CONTINUE READING

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