The effects of local DNA sequence on the interaction of ligands with their preferred binding sites.

Abstract

We have examined the effects of local DNA sequence on the interaction of distamycin, Hoechst 33258, echinomycin, actinomycin and mithramycin with their preferred binding sites using a series of DNA fragments that contain every symmetrical hexanucleotide sequence. In several instances we find that the affinity for the ligands' preferred binding sites is… (More)
DOI: 10.1016/j.biochi.2008.01.001

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