• Corpus ID: 22554981

The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet.

  title={The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet.},
  author={M Wierucka-Rybak and Monika Wolak and Ewa Bojanowska},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  volume={65 4},
High intake of fats and sugars has prompted a rapid growth in the number of obese individuals worldwide. To further investigate whether simultaneous pharmacological intervention in the leptin and cannabinoid system might change food and water intake, preferences for palatable foods, and body weight, we have examined the effects of concomitant intraperitoneal administration of leptin and AM 251, a cannabinoid 1 (CB1) receptor antagonist, or cannabidiol (CBD), a plant cannabinoid, in rats… 

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  • E. BojanowskaE. Radziszewska
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2011
The concomitant stimulation of GLP-1 receptor and blockade of CB1 receptor, however, may act synergistically to inhibit appetite in the rat.

The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats

The hypothesis that CB1 receptor antagonists could be useful pharmacological tools for the suppression of appetite is supported.

Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors

Leptin potentiates the anti-obesity effects of rimonabant.

Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.

Both age and an HF diet are associated with enhanced anorectic responses to AM251, but the underlying mechanism of these responses remains speculative.

Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.

The results indicate the existence of a functional synergistic interaction between leptin and CCK leading to early suppression of food intake which involves CCK-A receptors and capsaicin-sensitive afferent fibers.