• Corpus ID: 22554981

The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet.

@article{WieruckaRybak2014TheEO,
  title={The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet.},
  author={M Wierucka-Rybak and Monika Wolak and Ewa Bojanowska},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2014},
  volume={65 4},
  pages={
          487-96
        }
}
High intake of fats and sugars has prompted a rapid growth in the number of obese individuals worldwide. To further investigate whether simultaneous pharmacological intervention in the leptin and cannabinoid system might change food and water intake, preferences for palatable foods, and body weight, we have examined the effects of concomitant intraperitoneal administration of leptin and AM 251, a cannabinoid 1 (CB1) receptor antagonist, or cannabidiol (CBD), a plant cannabinoid, in rats… 

Figures and Tables from this paper

Can We Selectively Reduce Appetite for Energy-Dense Foods? An Overview of Pharmacological Strategies for Modification of Food Preference Behavior

TLDR
The most promising therapies and agents that influence the effectiveness of appetite-modifying drugs and systemically administered pharmaceuticals that impinge on the endogenous cannabinoid, opioid, aminergic, cholinergic, and peptidergic systems in the modification of food preference behavior are indicated.

Cannabinoids modulate food preference and consumption in Drosophila melanogaster

TLDR
It is shown that flies display preferences for consuming cannabinoids, independent of their sensory functions, and phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake.

The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease

TLDR
Results suggest that Abn-CBD exerts beneficial immunomodulatory actions in the liver, pancreas and adipose tissue of DIO prediabetic mice with NAFLD, thus protecting tissues and suggesting novel pharmacological strategies for managing obesity-related metabolic disorders.

Targeting the Endocannabinoid CB1 Receptor to Treat Body Weight Disorders: A Preclinical and Clinical Review of the Therapeutic Potential of Past and Present CB1 Drugs

TLDR
Preclinical and clinical studies suggest that ligands targeting the CB1 may retain the therapeutic potential of rimonabant without the negative side effect profile, and clearly point out the cannabinoid CB1 as a potential effective target for the treatment of obesity.

Cannabinoids, Chemical Senses, and Regulation of Feeding Behavior

TLDR
The CB1 receptor represents the most relevant target molecule of cannabinoid components on nervous system and whole-body energy homeostasis and can increase appetite and stimulate feeding, whereas blockade of CB1 suppresses hunger and induces hypophagia.

Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression

TLDR
CBD exerted a prohedonic effect in rats subjected to CUMS, demonstrated by the increased sucrose preference after three weeks of treatment, which might point toward an anxiolytic or antidepressant-like effect of CBD.

Effects of Δ9-Tetrahydrocannibinol (THC) on Obesity at Different Stages of Life: A Literature Review

TLDR
Examining the negative effects of obesity, and how the use of Δ9-tetrahydrocannibinol (THC) or cannabidiol (CBD) can impact rates of this global pandemic at different timepoints of life found a positive correlation between prenatal cannabis use and obesity rates in the children as they matured.

Cannabidiol inhibits sucrose self‐administration by CB1 and CB2 receptor mechanisms in rodents

TLDR
The present findings suggest that CBD may have therapeutic potential in reducing binge eating and the development of obesity.

Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus.

TLDR
The cannabinoid CP55940 administered to the PVN of urethane-anaesthetized rats can induce depressor and pressor effects, and the direction of the response probably depends on the sympathetic tone.

Explorative Placebo-Controlled Double-Blind Intervention Study with Low Doses of Inhaled Δ9-Tetrahydrocannabinol and Cannabidiol Reveals No Effect on Sweet Taste Intensity Perception and Liking in Humans

TLDR
It is suggested that administration of Cannabis preparations at the low doses tested does not affect sweet taste intensity perception and liking, nor does it influence food preferences in humans.

References

SHOWING 1-10 OF 49 REFERENCES

Concurrent pharmacological modification of cannabinoid-1 and glucagon-like peptide-1 receptor activity affects feeding behavior and body weight in rats fed a free-choice, high-carbohydrate diet

TLDR
It is concluded that AM 251 or WIN 55,212-2 and Ex-4, injected together, exert additive, inhibitory effects on the consumption of high-sugar food.

Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.

Combined stimulation of glucagon-like peptide-1 receptor and inhibition of cannabinoid CB1 receptor act synergistically to reduce food intake and body weight in the rat.

  • E. BojanowskaE. Radziszewska
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2011
TLDR
The concomitant stimulation of GLP-1 receptor and blockade of CB1 receptor, however, may act synergistically to inhibit appetite in the rat.

The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats

TLDR
The hypothesis that CB1 receptor antagonists could be useful pharmacological tools for the suppression of appetite is supported.

Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors

Leptin potentiates the anti-obesity effects of rimonabant.

Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.

TLDR
Both age and an HF diet are associated with enhanced anorectic responses to AM251, but the underlying mechanism of these responses remains speculative.

Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.

TLDR
The results indicate the existence of a functional synergistic interaction between leptin and CCK leading to early suppression of food intake which involves CCK-A receptors and capsaicin-sensitive afferent fibers.