The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs

  title={The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs},
  author={L. Yu and Jieqi Xiong and L. Guo and Lifang Miao and Si-sun Liu and F. Guo},
  • L. Yu, Jieqi Xiong, +3 authors F. Guo
  • Published 2015
  • Biology, Medicine
  • BioMetals
  • Lanthanide elements have been documented to possess various biologic effects, and their compounds have been studied intensely for their anti-cancer potential. However, the underlying mechanisms remain largely unknown. In the present study, we propose that the levels of proliferation and apoptosis related microRNAs (miRNAs), let-7a and miR-34a, which mediate the apoptosis of cervical cancer cells, can be affected by the lanthanum ion. Our data showed that LaCl3 inhibited the proliferation and… CONTINUE READING
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