The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs

  title={The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs},
  author={Lingfang Yu and Jieqi Xiong and Ling-yan Guo and Lifang Miao and Sisun Liu and Fei Guo},
Lanthanide elements have been documented to possess various biologic effects, and their compounds have been studied intensely for their anti-cancer potential. However, the underlying mechanisms remain largely unknown. In the present study, we propose that the levels of proliferation and apoptosis related microRNAs (miRNAs), let-7a and miR-34a, which mediate the apoptosis of cervical cancer cells, can be affected by the lanthanum ion. Our data showed that LaCl3 inhibited the proliferation and… 

Effects of the rare elements lanthanum and cerium on the growth of colorectal and hepatic cancer cell lines.

Anticancer effect of sodium metavanadate on murine breast cancer both in vitro and in vivo.

It is revealed that NaVO3 was able to inhibit proliferation of murine breast cancer cells 4T1 with IC50 value and exhibited a dose-dependent anticancer activity in breast cancer-bearing mice that led to the shrinkage of tumor volume, lower microvessel density, less propagating cells and more apoptotic cells in vivo, as compared to the saline group.

Lanthanum chloride enhances cisplatin-induced apoptosis in ovarian cancer cells.

The inhibitory effect of LaCl3 is determined on the COC1 growth when treated with Cisplatin, which may serve as a basis for the clinical application of La Cl3 in the treatment of ovarian cancer.

Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway

Data indicated that LaCl3 could be a potential drug to modulate DDP resistance by inactivating of PI3K/Akt pathway and attenuating DNA repair in ovarian cancer.

Upregulation of miR-9 and Let-7a by nanoencapsulated chrysin in gastric cancer cells

Chrysin–PLGA–PEG nanoparticles are more effective than pure chrysin in upregulation of miR-9 and Let-7a due to enhanced uptake by cells and could be a superior carrier for this kind of hydrophobic agent.

Development of double strand RNA mPEI nanoparticles and application in treating invasive breast cancer

dsRNA mPEI nanoparticles are able to effectively treat aggressive TNBC, and the mechanism studies reveal that they take effect by knocking-down Fra-1 relevant genes, hence interfering in transcription and translation of the genes, which are necessary for growth and metastasis of TNBC.

MicroRNA-26a inhibits the growth and invasiveness of malignant melanoma and directly targets on MITF gene

Looking at the effects of miR-26a and let-7a on the growth and invasiveness of malignant melanoma in vitro and in vivo, they are suggested to represent novel therapies for malignant skin cancer.

Biological activities of siRNA-loaded lanthanum phosphate nanoparticles on colorectal cancer.

  • Pi LiYi Yan Qiang Zhang
  • Biology, Chemistry
    Journal of controlled release : official journal of the Controlled Release Society
  • 2020

Circular RNA 0039411 Is Involved in Neodymium Oxide-induced Inflammation and Antiproliferation in a Human Bronchial Epithelial Cell Line via Sponging miR-93-5p.

Investigation of the underlying cytotoxicity of Nd2O3 in human bronchial epithelial cells (16HBE) and the potential mechanisms mediated by circular RNAs suggested that upregulation of circ_0039411 mediated Nd 2O3-induced inflammation and dysfunction by sponging miR-93-5p.

Integrated analysis of the miRNA, gene and pathway regulatory network in gastric cancer.

It is found that more than 4,000 unique genes are potential downstream targets of gastric cancer miRNAs, and these targets belong to the protein class of nucleic acid binding, transcription factor, enzyme modulator, transferase and receptor.



Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells

The results suggest that there is an intrinsic molecular pathway of cell apoptosis in [LaCit2]3−-treated SiHa cells and it provide a molecular mechanism underlying lanthanide citrate complex-mediated cell apoptotic.

[Effects of lanthanum chloride on proliferation and migration of human cervical cancer cell line HeLa cells].

Lanthanum chloride can inhibit the proliferation and migration of cervical cancer cells, and induce apoptosis by down-regulating cyclinD1, A20, and MMP-9 expressions in vitro.

Mir-34: A New Weapon Against Cancer?

Given the broad anti-oncogenic activity of miR-34a, the replacement of oncosuppressor miRNAs provides an effective strategy against tumor heterogeneity and the selective RNA-based delivery systems seems to be an excellent platform for a safe and effective targeting of the tumor.

The miR-34 family in cancer and apoptosis

The evidence for a role of miR-34a and miR/c in the apoptotic response of normal and tumor cells is surveyed and has been linked to resistance against apoptosis induced by p53 activating agents used in chemotherapy.

Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples.

Effects of rare earth compounds on growth and apoptosis of leukemic cell lines

The results indicate that at certain concentrations, the rare earth compounds may inhibit the growth of leukemic cells, induce them to apoptosis, and have no significant inhibitory effects on normal bone marrow hematopoietic progenitor cells (CFU-GM).

Microrna let-7: an emerging next-generation cancer therapeutic

Let-7 is underexpressed in various cancers, and restoration of its normal expression is found to inhibit cancer growth by targeting various oncogenes and inhibiting key regulators of several mitogenic pathways, and data suggest that let-7 regulates apoptosis and cancer stem cell differentiation and can be tested as a potential therapeutic in cancer treatment.

Lanthanum Induced Primary Neuronal Apoptosis Through Mitochondrial Dysfunction Modulated by Ca2+ and Bcl-2 Family

The results demonstrated that toxicity of lanthanum in cortical neurons perhaps partly attributed to enhanced mitochondrial apoptosis due to mitochondrial dysfunction modulated by Ca2+ and Bcl-2 family.

MicroRNA let-7a: a potential marker for selection of paclitaxel in ovarian cancer management.

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).