The effects of kindling on GABA-Mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression

@article{Tuff1982TheEO,
  title={The effects of kindling on GABA-Mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression},
  author={Lawrence Tuff and Ronald J. Racine and Richard Adamec},
  journal={Brain Research},
  year={1982},
  volume={277},
  pages={79-90}
}
Double-pulse stimulation of the perforant path input to the dentate gyrus was used in the following experiments to produce paired pulse depression in that site. This effect provided an estimate of GABA-mediated recurrent inhibition. The depression was enhanced by drugs that facilitate or mimic GABA action and attenuated by drugs which block GABA transmission. Paired-pulse depression was significantly increased following amygdala kindling and was further enhanced to near maximal levels by… CONTINUE READING
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