The effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis.

@article{Hemby1995TheEO,
  title={The effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis.},
  author={Scott E Hemby and Thomas J Martin and Conchita Co and Steven I. Dworkin and James E. Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={273 2},
  pages={591-8}
}
Dopaminergic innervations of the nucleus accumbens (NAcc) have a significant role in the brain processes underlying the reinforcing actions of abused drugs. In addition to the evidence from selective lesions and receptor antagonists, recent determinations of increased extracellular dopamine concentrations ([DA]e) in this structure during cocaine and ethanol self-administration have extended this notion. This study was undertaken to determine if the reinforcing effects of heroin were similarly… CONTINUE READING

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