The effects of intravenous endotoxin on various host-effector molecules.


To understand better the pathogenesis of gram-negative infections, we administered a single intravenous injection of Escherichia coli RE-2 endotoxin (4 ng/kg) to five normal volunteers and periodically measured various host-effector molecules in blood. All subjects had a significant (p less than 0.05) increase in temperature (maximum of 1.3 +/- 0.1 degrees… (More)