The effects of intracerebroventricularly injected corticotropin-releasing factor (CRF) on the central nervous system: behavioural and biochemical studies.

@article{Matsuzaki1989TheEO,
  title={The effects of intracerebroventricularly injected corticotropin-releasing factor (CRF) on the central nervous system: behavioural and biochemical studies.},
  author={Ichiyo Matsuzaki and Yukio Takamatsu and Takashi Moroji},
  journal={Neuropeptides},
  year={1989},
  volume={13 3},
  pages={147-55}
}
Intracerebroventricularly (ICV) administered corticotropin-releasing factor (CRF) produces behavioural activation in rats. The present study was designed to investigate the effects of ICV administered CRF on not only locomotor activity, but also the turnover rates of dopamine (DA) and norepinephrine (NE) in various discrete brain regions in rats. ICV administration of 1 microgram CRF produced a significant increase in locomotor activity, while ICV administration of 10 micrograms CRF caused slow… CONTINUE READING