The effects of interleukin-1 beta on the activity of adrenal, splenic and renal sympathetic nerves in the rat.

@article{Niijima1991TheEO,
  title={The effects of interleukin-1 beta on the activity of adrenal, splenic and renal sympathetic nerves in the rat.},
  author={Akira Niijima and Takafumi Hori and Shuji Aou and Yutaka Oomura},
  journal={Journal of the autonomic nervous system},
  year={1991},
  volume={36 3},
  pages={183-92}
}
The effects of intravenous (i.v.) administration of recombinant human interleukin-1 beta (rhIL-1 beta) on the activity of adrenal, splenic and renal sympathetic nerves were observed in urethane-anesthetized rats. An i.v. injection of IL-1 beta in doses of 10 pg-20 ng per animal (300-400 g, b.w.) resulted in a dose-dependent increase in the activity of the adrenal and splenic nerves, which lasted for more than 2-6 h. On the other hand, the activity of renal nerves showed a transient increase… CONTINUE READING
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