The effects of interferon beta treatment on arthritis.

  title={The effects of interferon beta treatment on arthritis.},
  author={P. P. Tak and Bert A.’t Hart and Maarten C. Kraan and Margaret Jonker and Tom J. M. Smeets and Ferdinand C. Breedveld},
  volume={38 4},
OBJECTIVE To determine whether interferon beta (IFN-beta) therapy might have a beneficial effect on arthritis, we evaluated the effect of IFN-beta on collagen type II-induced arthritis (CIA) in rhesus monkeys and conducted a pilot study in patients with rheumatoid arthritis (RA). METHODS Four rhesus monkeys with CIA were treated with 10 x 10(6) U (MIU)/kg mammalian cell-derived recombinant IFN-beta (Rebif; Ares-Serono) s.c. daily for 1 week. Subsequently, 12 patients with active RA were… CONTINUE READING