The effects of insulin-like growth factor-1 on plasminogen activator inhibitor-1 synthesis and secretion: results from in vitro and in vivo studies.

@article{Padayatty1993TheEO,
  title={The effects of insulin-like growth factor-1 on plasminogen activator inhibitor-1 synthesis and secretion: results from in vitro and in vivo studies.},
  author={S J Padayatty and Steve Orme and P. D. Zenobi and Max H. Stickland and Paul E Belchetz and Peter J. Grant},
  journal={Thrombosis and haemostasis},
  year={1993},
  volume={70 6},
  pages={1009-13}
}
In vitro studies have shown that insulin and IGF-1 releases the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1) from cells of hepatic origin. To investigate the effects of IGF-1 on fibrinolysis: 1) cultured hepatoma cells were grown in the presence of IGF-1 and media collected for secreted PAI-1 and cells probed for PAI-1 mRNA, 2) 8 hypopituitary patients were treated with recombinant human growth hormone (rhGH) and 3) 5 type 2 diabetic patients were treated with recombinant… CONTINUE READING

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